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KMID : 0869619950120010028
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Journal of Korean Society of Hospital Pharmacists
1995 Volume.12 No. 1 p.28 ~ p.32
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The Use of Antihypertensives in the Hypertensive Patients with Renal Disease
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Abstract
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Hypertension is a common complication of renal diseases. The prevalence of hypertension in renal diseases in about 80% chronic renal failure, 20% to 50% chronic glomerulonephritis and 40% IgA nephropathy. The factors influencing hypertension in renal diseases are an increase in total body salt and water also high plasma rennin level. Acceleration to decline the renal function is occurred in patients with high blood pressure. Therefore, optimal therapy of hypertension may be able to slow down the progression rate of renal disease. A blood pressure of less than 140/90㎜Hg has been considered to be adequate blood pressure for control. Antihypertensive effects in 45 hypertensive patients with renal diseases were evaluated before and after medication and how about the relation to progressive renal function and control to blood pressure. The results were as follows :
1. Before antihypertensive medication, serum creatinine concentration was 2.98 ±2.85㎎/㎗ and after medication 2.54±2.31㎎/㎗.
2. 66.7% patients needed less than 4 weeks to reduce below 90㎜Hg of diastolic blood pressure.
3. Frequency of antihypertensives were ACE inhibitors 93.3%, calcium channel blockers 86.7%, diuretics 55.6% and β-blockers 51.1%.
4. Combination rate of antihypertensives was 2.0±0.8.
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